PhenomeCentral is a repository for secure data sharing targeted at clinicians and scientists working in the rare disorder community. We encourage global scientific collaboration while respecting the privacy of patients profiled in this centralized database. PhenomeCentral uses state-of-the-art algorithms to match cases on phenotype and genotype. You can find similar cases even if there are no phenotypes in common, because terms are matched semantically rather than using textual similarity. You can enter candidate genes or let the Exomiser automatically prioritize genes from exome sequencing data.