Provided by DRESDEN-CONCEPT GENOME CENTER (DCGC)
Next generation sequencing (NGS) and associated technologies are available to researchers in the area of life sciences on the Dresden Campus of DCGC. It provides strong expertise in the areas of:
(1) Single cell applications;
(2) De novo genome sequencing and assemblies; and
(3) A broad range of short read-based sequencing application.
Services provided by EU-OPENSCREEN include
• high-throughput compound/ drug screening (HTS): HTS of an assay against the EU-OPENSCREEN chemical collection (> 100,000 compounds); in silico profiling; hit selection; confirmatory screening; basic
counter screening; basic SAR based on screening data; QC of confirmed hits
• access to a unique European compound collection: EU-OPENSCREEN chemical collection (> 100,000 compounds)
Services provided by EU-OPENSCREEN include
• assay adaption: This assay adaptation process will involve a strong emphasis on quality, including: quality control of reagents; (patho-)physiological relevance; pharmacological consistency; robustness; minimised variability; and tracking of statistical descriptors (e.g. signal to background and the Z’ factor)
• chemical optimization and profiling of preliminary ‘hits’
• bioprofiling of donated compounds: All compounds donated by the user which enter the EU-OPENSCREEN ERIC compound collection are characterised and annotated for basic physico-chemical (e.g. identity, solubility, light absorbance and fluorescence) and essential to know biological properties (cytotoxicity, antibiotic, antifungal etc.) by testing in a standard panel of assays.
• provision of standardised data: All data generated through QC/bioprofiling and screening activities will be published in EU-OPENSCREEN’s open-access database with an optional ‘grace’ period (i.e. delayed publication of data). Large-scale open-access data provide the basis for computational data integration to obtain a systematic view, allow for prediction of drug-target interactions and networks as well as of adverse effects and drug combinations. The access to the EU-OPENSCREEN database will utilize the facilities of ChEMBL.
EU-OPENSCREEN provides training and education activities in the aread of assay development, assay technologies, instrumentation and automation, compound management, and informatics.
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Euro-BioImaging offers numerous courses that teach you how to use various imaging technologies or analyze and process your results. The current portfolio includes:
Biological Imaging Courses
Biomedical Imaging Courses
Training Resources from Industry Partners
MSc degree programmes/MSc level internships/mobility
Through Euro-BioImaging, life scientists can access imaging instruments including biological (e.g. microscopy, mass spectrometryand, fluorescence spectroscopy based imaging) and multi-modal molecular and medical (PET, MRI, CT, SPECT) imaging, expertise, and data management services
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ESGI provides access to new genomic technologies and analytic tools, including
* DNA analysis
* Long Read analysis
* Transcriptome Analysis
*3D genomics
*single cell analysis
*Epigenomic Analysis
Provided by GERMAN CANCER RESEARCH CENTER GENOMICS & PROTEOMICS CORE FACILITY
Genomics and Proteomics Core Facility has integrated Many different services:
The Microarray Unit performs expression profiling of mRNA and miRNA, Genotyping and genome-wide methylation analysis.
High-Throughput sequencing is offered and monoclonal antibodies, stable isogenic recombinant cell lines and a clone and vector repository are available.
Additionally we provide booking of central GPCF equipment like Real Time PCR machines, sample preparation robots or SilverQuant scanning systems or the wetlab wiki, which allows you to share and discuss protocols with your colleagues at DKFZ.
Services offered by INFRAFRONTIER include
• Rodent Model Generation (generation of custom rodent mutant strains using the latest genome-editing technologies by expert laboratories)
• Cryopreservation (Mutant mouse models generated by researchers around the world are archived using the latest cryopreservation techniques in the European Mouse Mutant Archive (EMMA).
• Strain Distribution (The deposited mutant mouse lines are sent to researchers around the globe as frozen gametes or live cohorts.
• Mouse Phenotyping (These systematic phenotyping platforms incorporate whole-system screen covering different diseases and organ systems.
• Axenic Service (This service offers the germ-free derivation of user-provided mouse strains. These germ-free mice can be used for different gnotobiotic studies that shed light on the important contribution of the gut microbiota to health disease).
• Open Calls (free-of-charge cancer and infectious disease services funded by the European Commission).
• Cancer Services (Via the canSERV project, INFRAFRONTIER offers access to several cutting-edge cancer services as Trans-National Access calls).
The INFRAFRONTIER Research Infrastructure and its partners offer a wide range of state-of-the-art training opportunities: Mouse clinics in different European countries provide outstanding trainings in first-line mouse phenotyping as well as specialised phenotyping courses covering e.g. mouse osteology and mouse blood and lymphatic vessel phenotyping.
The INFRAFRONTIER courses cover unique training opportunities in mouse model development as well as hands on cryopreservation courses offered by EMMA partners for many years.
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