The TRND program supports preclinical development of therapeutic candidates intended to treat rare or neglected disorders, with the goal of enabling an Investigational New Drug application.
View this resource Bookmark this resourceSmall Molecules
analysis of the attrition of drug candidates from four major pharmaceutical companies
Published by Macmillan Publishers Limited
Drug DiscoverySafety IssueSmall MoleculeThis paper describes the compilation and analysis of combined data on the attrition of drug candidates from AstraZeneca, Eli Lilly and Company, GlaxoSmithKline and Pfizer. The analysis reaffirms that control of physicochemical properties during compound optimization is beneficial in identifying compounds of candidate drug quality and indicates for the first time a link between the physicochemical properties of compounds and clinical failure due to Safety Issues.
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MDC Connects: A Guide to Drug Discovery
Published by Medicines Discovery Catapult
Drug DiscoverySmall MoleculesTarget IdentificationThis guideline is a summary presentation from the Medicines Discovery Catapult (MDC) webinars. The aim was to create a resource of modern drug discovery knowledge to support small companies who are developing their own medicines. The guideline is focused on preclinical research with an emphasis on small molecules in the following topics:
• What makes, and how to identify, a good target
• Methods to identify the chemical compound which would become the drug
• How to optimise that drug
• How to test it works in models of disease
• And how to demonstrate that it would be safe to dose in humans
Genetic-Driven Druggable Target Identification and Validation
Published by Trends Genet.
Expression Quantitative Trait LocusGenetic ToolboxGWAS AssociationTarget IdentificationThis article reviews the opportunities and challenges, and infer criteria for the optimal use of genetic findings in the drug discovery pipeline. Choosing the right biological target is the critical primary decision for the development of new drugs. Systematic genetic association testing of both human diseases and quantitative traits, along with resultant findings of coincident associations between them, is becoming a powerful approach to infer drug targetable candidates and generate in vitro tests to identify compounds that can modulate them therapeutically
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Drug discovery and development: Role of basic biological research
Published by Alzheimers Dement (N Y).
Drug DiscoveryTarget ValidationThis article provides a brief overview of the processes of drug discovery and development. The aim is to help scientists whose research may be relevant to drug discovery and/or development to frame their research report in a way that appropriately places their findings within the drug discovery and development process and thereby support effective translation of preclinical research to humans.
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Genome-Wide Association Studies Fact Sheet
Published by NHGRI
Genome-Wide AssociationTarget IdentificationGuideline to conduct Genome-wide association studies. This studies involve scanning markers across the genomes of many people to find genetic variations associated with a particular disease. It is an interesting tool to help find diseases targets
View this resource Bookmark this resourcePubChem is an open chemistry database at the National Institutes of Health (NIH). PubChem mostly contains Small Molecules, but also larger molecules such as nucleotides, carbohydrates, lipids, peptides, and chemically-modified macromolecules.It collects information on Chemical Structures, identifiers, chemical and physical properties, biological activities, patents, health, Safety, toxicity data, and many others
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A Specialized Platform for Innovative Research Exploration (ASPIRE)
Published by NCATS
ASPIREReproducibilitySmall MoleculeBy addressing long-standing challenges in the field of chemistry, including lack of standardization, low Reproducibility and an inability to predict how new chemicals will behave, ASPIRE is designed to bring novel, safe and effective treatments to more patients more quickly at lower cost.
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