Drug Discovery

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Open access In Silico Tools to predict the ADMET profiling of drug candidates

Published by Expert Opinion on Drug Discovery

Drug DiscoveryIn Silico ToolLead OptimisationTarget Identification

This review meticulously encompasses the fundamental functions of open access in silico prediction tools (webservers and standalone software) and advocates their use in drug discovery research for the Safety and reliability of any candidate-drug. This review also aims to help support new researchers in the field of drug design.

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analysis of the attrition of drug candidates from four major pharmaceutical companies

Published by Macmillan Publishers Limited

Drug DiscoverySafety IssueSmall Molecule

This paper describes the compilation and analysis of combined data on the attrition of drug candidates from AstraZeneca, Eli Lilly and Company, GlaxoSmithKline and Pfizer. The analysis reaffirms that control of physicochemical properties during compound optimization is beneficial in identifying compounds of candidate drug quality and indicates for the first time a link between the physicochemical properties of compounds and clinical failure due to Safety Issues.

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Drug Repurposing: progress, challenges and recommendations

Published by Nature Reviews Drug Discovery

Drug DiscoveryDrug RepurposingResearch and Drug Development

In this Article, it is presented approaches used for Drug Repurposing (also known as drug repositioning), discussed the challenges faced by the repurposing community and recommended innovative ways by which these challenges could be addressed to help realize the full potential of Drug Repurposing.

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ATMP guidebook for innovators in the Netherlands

Published by FAST

ATMPDrug DiscoveryGuideline

This Guidebook is primarily designed to help you navigate the European and Dutch ATMP landscape, offering a deeper
understanding of the required and optional steps and activities at each stage of the ATMP pathway. It also serves as a collaborative tool, helping you engage with external experts across various specialized topics critical to successful ATMP development

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MDC Connects: A Guide to Drug Discovery

Published by Medicines Discovery Catapult

Drug DiscoverySmall MoleculesTarget Identification

This guideline is a summary presentation from the Medicines Discovery Catapult (MDC) webinars. The aim was to create a resource of modern drug discovery knowledge to support small companies who are developing their own medicines. The guideline is focused on preclinical research with an emphasis on small molecules in the following topics:
• What makes, and how to identify, a good target
• Methods to identify the chemical compound which would become the drug
• How to optimise that drug
• How to test it works in models of disease
• And how to demonstrate that it would be safe to dose in humans

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Drug discovery and development: Role of basic biological research

Published by Alzheimers Dement (N Y).

Drug DiscoveryTarget Validation

This article provides a brief overview of the processes of drug discovery and development. The aim is to help scientists whose research may be relevant to drug discovery and/or development to frame their research report in a way that appropriately places their findings within the drug discovery and development process and thereby support effective translation of preclinical research to humans.

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Tissue Chip for Drug Screening program and Consortium

Published by IRDiRC

BiomarkerDrug DiscoveryDrug Screening ProgrammeHigh Throughput ScreeningLibraryNCATSResearch and Drug DevelopmentTissue Chip

NCATS, in collaboration with other NIH Institutes and Centers and the Food and Drug Administration (FDA), is leading the Tissue Chip for Drug Screening program to develop human tissue chips that accurately model the structure and function of human organs — such as the lungs, liver and heart — to help predict drug Safety in humans more rapidly and effectively

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Development of product specific bio-analytical assays 

Published by IRDiRC

Bio-Analytical AssayBioassayDrug DiscoveryResearch and Drug Development

Measurement of drug concentrations in biological matrices (such as serum, plasma, blood, urine, and saliva) is an important aspect of drug development. These methods provide data to support the Safety and effectiveness of drugs, which may be needed to support applications for new drugs in regulatory pathways

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