This article is a review of the main concepts about In silico modeling of diseases. Examples and applications of In silico modeling for some important categories of diseases (such as for cancers, infectious diseases, and neuronal diseases) are also given.
View this resource Bookmark this resourceIn silico
This website provides In silico modeling tools to measure key aspects affecting the performance of nanomedicines release. It offers physiologically-based biopharmaceutics (PBB) modeling with the aims to support the development of the novel in vitro methods.
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In Silico Model in Toxicology and Risk Assessment
Published by Frontiers Media
In silicophysiologically-based kinetic and dynamic modelQSAR modelThis article aims to address the latest developments in the area of In silico modelling and New approach methodologies (NAMs) including physiologically-based kinetic and dynamic (PBK-D) model, In silico model for the prediction of toxicological such as QSAR model and machine learning algorithms, the use of quantitative adverse outcome pathways for hazard characterisation of chemicals to cite but a few
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A European standardization framework for data integration and data-driven In Silico Model for personalized medicine – EU-STANDS4PM
Published by EU-STANDS4PM consortium
ethicalIn silicoLegalThis report therefore surveys the legal landscape for health data integration, and the challenges which arise when information is re-used to develop analytical or predictive model, which are then re-applied to a patient population
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In silico Methods for Drug Design and Discovery
Published by Computers in Biology and Medicine
In sillicomethodstoolsIn this review,is briefly introduced computational drug discovery strategies and outline up-to-date tools to perform the strategies as well as available knowledge bases for those who develop their own computational model.
View this resource Bookmark this resourceJaqpot is a computational platform for in silico modelling of chemical compounds, that provides both access to its services both over a User Interface (GUI) and an Application Programming Interface (API). It is a cloud-ready application that uses the benefits of Java, R and Python, having incorporated functionality by various established and open-source machine learning and data analysis toolkits, while algorithms in any programming algorithm can be added to Jaqpot. A new version of the UI and API is in preparation and will be released within 2019
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Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model
Published by CPT Pharmacometrics & Systems Pharmacology
In silicopharmacokinetic/pharmacodynamic (PBPK/PD) modelingThe aim of this tutorial is to introduce the fundamental concepts of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their practical implementation in a typical PBPK model building workflow
View this resource Bookmark this resourceSBML is a software data format for describing models in biology. It’s a little like HTML, but for formal models instead of web pages. It’s independent of any particular software tool and not limited to any particular field of the life sciences. It’s open and free.
View this resource Bookmark this resourceNeuroML is an international, collaborative initiative to develop a language and associated software tools for describing detailed models of neural systems.
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Modeling within-Host SARS-CoV-2 Infection Dynamics and Potential Treatments
Published by Viruses
In silicoInmune response modellingSARS-Cov-2This study describes the development of a mathematical model to simulate the actions of drugs that target SARS-CoV-2 virus infection.
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