The CCAC guidelines: Nonhuman primates provides information for investigators, animal care committees, facility managers, veterinarians and animal care staff to help facilitate improvement in both the care given to nonhuman primates and the manner in which experimental procedures are carried out
View this resource Bookmark this resourceDisease Model
In this section you will have the opportunity to explore cellular models:
patient-derived immortalized cell lines, and animal models
Patient-derived induced pluripotent stem cell (iPSCs)
Organoid
You can also find information regarding animal models:
Zebra Fish
Fruit fly
Mouse
Rat
Non-human primates
Jaqpot is a computational platform for in silico modelling of chemical compounds, that provides both access to its services both over a User Interface (GUI) and an Application Programming Interface (API). It is a cloud-ready application that uses the benefits of Java, R and Python, having incorporated functionality by various established and open-source machine learning and data analysis toolkits, while algorithms in any programming algorithm can be added to Jaqpot. A new version of the UI and API is in preparation and will be released within 2019
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Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model
Published by CPT Pharmacometrics & Systems Pharmacology
In silicopharmacokinetic/pharmacodynamic (PBPK/PD) modelingThe aim of this tutorial is to introduce the fundamental concepts of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their practical implementation in a typical PBPK model building workflow
View this resource Bookmark this resourceSBML is a software data format for describing models in biology. It’s a little like HTML, but for formal models instead of web pages. It’s independent of any particular software tool and not limited to any particular field of the life sciences. It’s open and free.
View this resource Bookmark this resourceNeuroML is an international, collaborative initiative to develop a language and associated software tools for describing detailed models of neural systems.
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Modeling within-Host SARS-CoV-2 Infection Dynamics and Potential Treatments
Published by Viruses
In silicoInmune response modellingSARS-Cov-2This study describes the development of a mathematical model to simulate the actions of drugs that target SARS-CoV-2 virus infection.
View this resource Bookmark this resourceThis Platform helps communities find, register and benchmark software tools. These tools help researchers access, analyse and integrate biological data, and so drive scientific discovery across the life sciences.
View this resource Bookmark this resourceCOSYS is an open computational platform designed for the Systems Biology community. Designed to help life scientists to easily access basilar systems biology tools, it can be also used with effectiveness by skilled systems biologists. Cooperation-driven and user-friendly, COSYS is a unified tool for biological modeling (mechanistic and constraint-based), simulation and analysis, providing users with the cutting edge of GPU-powered computation. COSYS is free of charge, and can be used by everyone.
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In-silico trial of intracranial flow diverters replicates and expands insights from conventional clinical trials
Published by Nature Communications
Clinical TrialsIn silicovirtual patientsIn-silico trials rely on virtual populations and interventions simulated using patient-specific model and may offer a solution to lower these costs. In this article, It is presented the flow diverter performance assessment (FD-PASS) in-silico trial, which model the treatment of intracranial aneurysms in 164 virtual patients with 82 distinct anatomies with a flow-diverting stent, using computational fluid dynamics to quantify post-treatment flow reduction
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How In Silico Modelling is Changing Our Approach to Drug Development and Clinical Research
Published by Proventa International
In silicoThis article introduces In silico modelling concepts and how these models are changing the drug development and the clinical research.
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