Chemistry technology experts at NCATS develop Small Molecules and screening approaches that other scientists can use to pursue innovations in therapeutic development.
View this resource Bookmark this resourceHigh Throughput Screening (HTS)
Phenotypic versus Target-Based Screening for Drug Discovery
Published by Technology Networks Drug Discoery
Drug DiscoveryPhenotypic ScreeningTarget-Based ScreeningTarget-Based Screening has been the method of choice in drug discovery for the past two decades, but Phenotypic Screening is having something of a renaissance. In this article the authors look at the advantages and applications of both.
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Matrix Combination Screening
Published by NCATS
Hight Throughput ScreeningLead ValidationMatrix CombinationNCATS experts use a technology called Matrix Combination screening to quickly narrow down a long list of potential drug combinations and find those with the most potential to help patients.
View this resource Bookmark this resourceThe goal of the NCATS 3-D Tissue Bioprinting program is to advance the process of discovery and development of new medicines by developing new assay models that better predict the effects of drugs in humans. 3-D Tissue Models that mimic characteristics of live human tissues are produced on microplates to test effectiveness and toxicity of Small Molecules or other therapeutic.
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Assay Development and Screening Technology (ADST)
Published by NCATS
High Throughput ScreeningNCATSSmall MoleculeOne of the first steps in the drug development process is creating test systems — called assays — on which researchers assess the effects of chemical compounds on cellular, molecular or biochemical processes of interest. At NCATS, the experts in the Assay Development and Screening Technology (ADST) program work to optimize assays requested or submitted by the biomedical research community for high-throughput small-molecule screening
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Tissue Chip for Drug Screening program and Consortium
Published by IRDiRC
BiomarkerDrug DiscoveryDrug Screening ProgrammeHigh Throughput ScreeningLibraryNCATSResearch and Drug DevelopmentTissue ChipNCATS, in collaboration with other NIH Institutes and Centers and the Food and Drug Administration (FDA), is leading the Tissue Chip for Drug Screening program to develop human tissue chips that accurately model the structure and function of human organs — such as the lungs, liver and heart — to help predict drug Safety in humans more rapidly and effectively
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