Drug Discovery

In this section you may find information about technologies and approach in novel drug discovery

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Drug Repurposing: progress, challenges and recommendations

Published by Nature Reviews Drug Discovery

Drug DiscoveryDrug RepurposingResearch and Drug Development

In this Article, it is presented approaches used for Drug Repurposing (also known as drug repositioning), discussed the challenges faced by the repurposing community and recommended innovative ways by which these challenges could be addressed to help realize the full potential of Drug Repurposing.

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ATMP guidebook for innovators in the Netherlands

Published by FAST

ATMPDrug DiscoveryGuideline

This Guidebook is primarily designed to help you navigate the European and Dutch ATMP landscape, offering a deeper
understanding of the required and optional steps and activities at each stage of the ATMP pathway. It also serves as a collaborative tool, helping you engage with external experts across various specialized topics critical to successful ATMP development

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Repurposing Medicines Toolkit – Guidance for navigating the process

Published by Life Arc, Medical Research Council (MRC)

GuidelineLife ArcRepurposing

this toolkit aims to provide a guide for researchers, charities and others embarking on repurposing projects. It highlights common activities, issues and considerations at each development stage and signpost to other available resources. The content is mostly styled as questions – what should I be considering at each development stage? It is intended to stimulate thinking and not as a step-by-step guide, which reflects the variable nature of repurposing.

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MDC Connects: A Guide to Drug Discovery

Published by Medicines Discovery Catapult

Drug DiscoverySmall MoleculesTarget Identification

This guideline is a summary presentation from the Medicines Discovery Catapult (MDC) webinars. The aim was to create a resource of modern drug discovery knowledge to support small companies who are developing their own medicines. The guideline is focused on preclinical research with an emphasis on small molecules in the following topics:
• What makes, and how to identify, a good target
• Methods to identify the chemical compound which would become the drug
• How to optimise that drug
• How to test it works in models of disease
• And how to demonstrate that it would be safe to dose in humans

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Genetic-Driven Druggable Target Identification and Validation

Published by Trends Genet.

Expression Quantitative Trait LocusGenetic ToolboxGWAS AssociationTarget Identification

This article reviews the opportunities and challenges, and infer criteria for the optimal use of genetic findings in the drug discovery pipeline. Choosing the right biological target is the critical primary decision for the development of new drugs. Systematic genetic association testing of both human diseases and quantitative traits, along with resultant findings of coincident associations between them, is becoming a powerful approach to infer drug targetable candidates and generate in vitro tests to identify compounds that can modulate them therapeutically

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5 Target Deconvolution Approaches in Drug Discovery

Published by Technology Networks Drug Discoery

Affinity ChromatographyBiochemical SuppressionCell MicroarrayExpression-CloningProtein MicroarrayTarget Deconvolution

The retrospective identification of the drug targets that underlie an observed phenotypic response is termed Target Deconvolution. Target Deconvolution can be achieved by numerous methods including; Affinity Chromatography, Expression-Cloning, Protein Microarray, ‘reverse transfected’ Cell Microarray, and Biochemical Suppression

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Exploring The Structure-Activity Relationship (SAR) of Drugs

Published by AZO LIFE SCIENCE

In Silico ToolLead OptimisationStructure-Activity RelationshipTarget Validation

The Structure-Activity Relationship (SAR) aids in understanding various aspects of drug discovery, from screening drug candidates to optimizing their properties. The effective biological activity is contributed by the various geometric and electrostatic interactions. This article introduce in a briefly way the diferent uses of The Structure-Activity Relationship (SAR) in drug discovery.

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Functional Genomics Lab

Published by NCATS

NCATSRNAi ScreeningTarget Identification

NCATS’ Functional Genomics Lab is designed to develop and improve RNAi Screening approaches to better understand gene function and identify treatment targets. Gene silencing through RNAi has emerged as a powerful tool for understanding gene function. Over the past several years, high-throughput RNAi screens have illuminated a wide variety of biological processes, ranging from genes that affect the activity of therapeutic agents to novel components of signaling pathways.

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Drug discovery and development: Role of basic biological research

Published by Alzheimers Dement (N Y).

Drug DiscoveryTarget Validation

This article provides a brief overview of the processes of drug discovery and development. The aim is to help scientists whose research may be relevant to drug discovery and/or development to frame their research report in a way that appropriately places their findings within the drug discovery and development process and thereby support effective translation of preclinical research to humans.

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