In this section you may find information about technologies and approach in novel drug discovery
Published by NCATS
RepurposingThe New Therapeutic Uses program aims to improve the process of developing new treatments and cures for disease by finding new uses for assets that already have cleared several key steps along the development path (also known as Drug Repurposing).
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View this resource Bookmark this resourceThis NCATS-led pilot project will test whether it is possible to increase the efficiency of Gene Therapy clinical trial startup by using the same Gene Delivery System and manufacturing methods for multiple gene therapies.
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Animal ModelBiologicsCell ModelDrug DiscoveryHigh Throughput ScreeningSmall MoleculesTarget IdentificationDiscovery Medicine is an evidence-based, peer-reviewed, open-access, and scholarly biomedical journal indexed in MEDLINE/PubMed by the U.S. National Library of Medicine. It is a premier source of important information, knowledge, and insights in translational and clinical research
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BiomarkerDrug DiscoveryDrug Screening ProgrammeHigh Throughput ScreeningLibraryNCATSResearch and Drug DevelopmentTissue ChipNCATS, in collaboration with other NIH Institutes and Centers and the Food and Drug Administration (FDA), is leading the Tissue Chip for Drug Screening program to develop human tissue chips that accurately model the structure and function of human organs — such as the lungs, liver and heart — to help predict drug Safety in humans more rapidly and effectively
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Bio-Analytical AssayBioassayDrug DiscoveryResearch and Drug DevelopmentMeasurement of drug concentrations in biological matrices (such as serum, plasma, blood, urine, and saliva) is an important aspect of drug development. These methods provide data to support the Safety and effectiveness of drugs, which may be needed to support applications for new drugs in regulatory pathways
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Drug Discovery GuidelineDrug RepurposingNCATSNIHResearch and Drug DevelopmentSmall MoleculeTarget Validation Drug DevelopmentThis manual is a comprehensive resource for early drug discovery, providing guidelines for developing therapeutic hypotheses, validating targets and pathways, and establishing proof of concept criteria. It includes analyses of costs at various stages of drug development. The content encompasses critical decision-making points in New Chemical Entity (NCE) development, exploratory Investigational New Drug (IND) processes, and orphan drug designation. Furthermore, it delves into Drug Repurposing and drug delivery technologies, making it an invaluable guide for professionals initiating new drug discovery and development programs.
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Drug DiscoveryDrug RepurposingGenericResearch and Drug DevelopmentOverview of the drug repositioning benefits both its public health benefits and its commercial value.
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Big DataCrowdfundingDrug DiscoveryDrug RepurposingIntellectual PropertyNeglected DiseasePrecision MedicineRare DiseaseResearch and Drug DevelopmentArticle that cover the most significant challenges and opportunities in Drug Repurposing.
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Clinical TrialDrug DiscoveryDrug RepurposingLead MoleculeResearch and Drug DevelopmentThis review provides different approaches for Drug Repurposing and addresses recent developments and future scope of drug repositioning strategies. In addition provides a list of repurposed drugs and repurposing resources.
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